• 1
    Melchers, F. and Rolink, A., B-lymphocyte development and biology . In Paul, W. E. (Ed.)Fundamental Immunology, 4th edn. Lippincott-Raven, Philadelphia 1998 pp 183224.
  • 2
    Rolink, A. G., Schaniel, C., Andersson, J. and Melchers, F., Selection events operating at various stages in B cell development. Curr. Opin. Immunol. 2001. 13: 202207.
  • 3
    Rolink, A. G., Andersson, J. and Melchers, F., Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity. Eur. J. Immunol. 1998. 28: 37383748.
  • 4
    Rolink, A. G., Brocker, T., Bluethmann, H., Kosco-Vilbois, M. H., Andersson, J. and Melchers, F., Mutations affecting either generation or survival of cells influence the pool size of mature B cells. Immunity 1999. 10: 619628.
  • 5
    Allman, D. M., Ferguson, S. E. and Cancro, M. P., Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigens and exhibit unique signaling characteristics. J. Immunol. 1992. 149: 25332540.
  • 6
    Allman, D. M., Ferguson, S. E., Lentz, V. M. and Cancro, M. P., Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J. Immunol. 1993. 151: 44314444.
  • 7
    Allman, D., Lindsley, R. C., DeMuth, W., Rudd, K., Shinton, S. A. and Hardy, R. R., Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J. Immunol. 2001. 167: 68346840.
  • 8
    Forster, I. and Rajewsky, K., The bulk of the peripheral B cell pool in mice is stable and not rapidly renewed from the bonemarrow. Proc. Natl. Acad. Sci. USA 1990. 87: 47814784.
  • 9
    Thomas-Vaslin, V. and Freitas, A. A., Lymphocyte population kinetics during the development of the immune system. B cell persistence and life-span can be determined by the host environment. Int. Immunol. 1989. 1: 237246.
  • 10
    Sprent, J., Lifespans of naive, memory and effector lymphocytes. Curr. Opin. Immunol. 1993. 5: 433438.
  • 11
    King, L. B. and Monroe, J. G., Immunobiology of the immature B cell: plasticity in the B cell antigen receptor-induced response fine tunes negative selection. Immunol. Rev. 2000. 176: 86104.
  • 12
    Nemazee, D. A. and Burki, K., Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 1989. 337: 562566.
  • 13
    Erikson, J., Radic, M. Z., Camper, S. A., Hardy, R. R., Carmack, C. and Weigert, M., Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 1991. 349: 331334.
  • 14
    Petrenko, O., Beavis, A., Klaine, M., Kittappa, R., Godin, I. and Lemischka, I. R., The molecular characterization of the fetal stem cell marker AA4. Immunity 1999. 10: 691700.
  • 15
    Norsworthy, P. J., Taylor, P. R., Walport, M. J. and Botto, M., Cloning of the mouse homolog of the 126-kDa human C1q/MBL/SP-A receptor, C1qR(p), Mamm. Genome 1999. 10: 789793.
  • 16
    Loder, F., Mutschler, B., Ray, R. J., Paige, C. J., Sideras,P., Torres, R., Lamers, M. C. and Carsetti, R., B cell development in the spleen takes placein discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 1999. 190: 7589.
  • 17
    Schneider, P., MacKay, F., Steiner, V., Hofmann, K., Bodmer,J. L., Holler, N., Ambrose, C., Lawton, P., Bixler, S., Acha-Orbea, H., Valmori, D., Romero, P., Werner-Favre, C., Zubler, R. H., Browning, J. L. and Tschopp, J., BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med. 1999. 189: 17471756.
  • 18
    Shu, H. B., Hu, W. H. and Johnson, H., TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukoc. Biol. 1999. 65: 680683.
  • 19
    Mukhopadhyay, A., Ni, J., Zhai, Y., Yu, G. L. and Aggarwal, B. B., Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase. J. Biol. Chem. 1999. 274: 1597815981.
  • 20
    Moore, P. A., Belvedere, O., Orr, A., Pieri, K., LaFleur, D. W., Feng, P., Soppet, D., Charters, M., Gentz, R., Parmelee, D., Li, Y., Galperina, O., Giri, J., Roschke, V., Nardelli, B., Carrell, J., Sosnovtseva, S., Greenfield, W., Ruben, S. M., Olsen, H. S., Fikes, J. and Hilbert, D. M., BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999. 285: 260263.
  • 21
    Gross, J. A., Johnston, J., Mudri, S., Enselman, R., Dillon,S. R., Madden, K., Xu, W., Parrish-Novak, J., Foster, D., Lofton-Day, C., Moore, M., Littau, A., Grossman, A., Haugen, H., Foley, K., Blumberg, H., Harrison, K., Kindsvogel, W. and Clegg, C. H., TACI and BCMA are receptors for a TNF homologue implicated in B cell autoimmune disease. Nature 2000. 404: 995999.
  • 22
    Batten, M., Groom, J., Cachero, T. G., Qian, F., Schneider, P., Tschopp, J., Browning, J. L. and Mackay, F., BAFF mediates survival of peripheral immature B lymphocytes. J. Exp. Med. 2000. 192: 14531466.
  • 23
    Schneider, P., Takatsuka, H., Wilson, A., Mackay, F., Tardivel, A., Lens, S., Cachero, T. G., Finke, D., Beermann, F. and Tschopp, J., Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. J. Exp. Med. 2001. 194: 16911697.
  • 24
    Gross, J. A., Dillon, S. R., Mudri, S., Johnston, J., Littau, A., Roque, R., Rixon, M., Schou, O., Foley, K. P., Haugen, H., McMillen, S., Waggie, K., Schreckhise, R. W., Shoemaker, K., Vu, T., Moore, M., Grossman, A. and Clegg, C. H., TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. Impaired B cell maturation in mice lacking BLyS. Immunity 2001. 15: 289302.
  • 25
    Thompson, J. S., Schneider, P., Kalled, S. L., Wang, L., Lefevre, E. A., Cachero, T. G., MacKay, F., Bixler, S. A., Zafari, M., Liu, Z. Y., Woodcock, S. A., Qian, F., Batten, M., Madry, C., Richard, Y., Benjamin, C. D., Browning, J. L., Tsapis, A., Tschopp, J. and Ambrose, C., BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population. J. Exp. Med. 2000. 192: 129135.
  • 26
    Thompson, J. S., Bixler, S. A., Qian, F., Vora, K., Scott, M. L., Cachero, T. G., Hession, C., Schneider, P., Sizing, I. D., Mullen, C., Strauch, K., Zafari, M., Benjamin, C. D., Tschopp, J., Browning, J. L. and Ambrose, C., BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 2001. 293: 21082111.
  • 27
    Xia, X. Z., Treanor, J., Senaldi, G., Khare, S. D., Boone, T., Kelley, M., Theill, L. E., Colombero, A., Solovyev, I., Lee, F., McCabe, S., Elliott, R., Miner, K., Hawkins, N., Guo, J., Stolina, M., Yu, G., Wang, J., Delaney, J., Meng,S. Y., Boyle, W. J. and Hsu, H., TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation. J. Exp. Med. 2000. 192: 137143.
  • 28
    Marsters, S. A., Yan, M., Pitti, R. M., Haas, P. E., Dixit, V. M. and Ashkenazi, A., Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr. Biol. 2000. 10: 785788.
  • 29
    Shu, H. B. and Johnson, H., B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. Proc. Natl. Acad. Sci. USA 2000. 97: 91569161.
  • 30
    Wu, Y., Bressette, D., Carrell, J. A., Kaufman, T., Feng, P., Taylor, K., Gan, Y., Cho, Y. H., Garcia, A. D., Gollatz,E., Dimke, D., LaFleur, D., Migone, T. S., Nardelli, B., Wei, P., Ruben, S. M., Ullrich, S. J., Olsen, H. S., Kanakaraj, P., Moore, P. A. and Baker, K. P., Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS. J. Biol. Chem. 2000. 275: 3547835485.
  • 31
    Gras, M. P., Laabi, Y., Linares-Cruz, G., Blondel, M. O., Rigaut, J. P., Brouet, J. C., Leca, G., Haguenauer-Tsapis, R. and Tsapis, A., BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes. Int. Immunol. 1995. 7: 10931106.
  • 32
    Mackay, F., Woodcock, S. A., Lawton, P., Ambrose, C., Baetscher, M., Schneider, P., Tschopp, J. and Browning, J. L., Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 1999. 190: 16971710.
  • 33
    Khare, S. D., Sarosi, I., Xia, X. Z., McCabe, S., Miner, K., Solovyev, I., Hawkins, N., Kelley, M., Chang, D., Van, G., Ross, L., Delaney, J., Wang, L., Lacey, D., Boyle, W. J. and Hsu, H., Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice. Proc. Natl. Acad. Sci. USA 2000.97: 33703375.
  • 34
    Schiemann, B., Gommerman, J. L., Vora, K., Cachero, T. G., Shulga-Morskaya, S., Dobles, M., Frew, E. and Scott, M. L., An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 2001. 293: 21112114.
  • 35
    Rolink, A. G., Winkler, T., Melchers, F. and Andersson, J., Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment. J. Exp. Med. 2000. 191: 2332.
  • 36
    Lam, K. P., Kuhn, R. and Rajewsky, K., In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 1997. 90: 10731083.
  • 37
    Neuberger, M. S., Antigen receptor signaling gives lymphocytes a long life. Cell 1997. 90: 971973.
  • 38
    Wang, H., Marsters, S. A., Baker, T., Chan, B., Lee, W. P., Fu, L., Tumas, D., Yan, M., Dixit, V. M., Ashkenazi, A. and Grewal, I. S., TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nat. Immunol. 2001. 2: 632637.
  • 39
    Miller, D. J. and Hayes, C. E., Phenotypic and genetic characterization of a unique B lymphocyte deficiency in strain A/WySnJ mice. Eur. J. Immunol. 1991. 21: 11231130.
  • 40
    Miller, D. J., Hanson, K. D., Carman, J. A. and Hayes, C. E., A single autosomal gene defect severely limits IgG but not IgM responses in B lymphocyte-deficient A/WySnJ mice. Eur. J. Immunol. 1992. 22: 373379.
  • 41
    Lentz, V. M., Cancro, M. P., Nashold, F. E. and Hayes, C. E., Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse. J. Immunol. 1996. 157: 598606.
  • 42
    Xu, S. and Lam, K. P., B cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Mol. Cell. Biol. 2001. 21: 40674074.
  • 43
    Yan, M., Marsters, S. A., Grewal, I. S., Wang, H., Ashkenazi, A. and Dixit, V. M., Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat. Immunol. 2000. 1: 3741.
  • 44
    von Bulow, G. U., van Deursen, J. M. and Bram, R. J., Regulation of the T-independent humoral response by TACI. Immunity 2001. 14: 573582.
  • 45
    Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. and Riccardi, C., A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 1991. 139: 271279.