1522-2594/asset/MRM_left.gif?v=1&s=5969df2beb44a0574452410c77dd4f39f1258c50)
1522-2594/asset/MRM_right.gif?v=1&s=5393eec9f654b39630b945fd1b37ae8304304345)
Note
Quantifying tracer levels of 2H2O enrichment from microliter amounts of plasma and urine by 2H NMR
Article first published online: 2 JAN 2001
DOI: 10.1002/1522-2594(200101)45:1<156::AID-MRM1020>3.0.CO;2-Z
Copyright © 2001 Wiley-Liss, Inc.
1522-2594/asset/cover.gif?v=1&s=9512352d4133369aa19bc75e4ffa8001ea23b2d9 "Magnetic Resonance in Medicine")
Additional Information
How to Cite
Jones, J. G., Merritt, M. and Malloy, C. (2001), Quantifying tracer levels of 2H2O enrichment from microliter amounts of plasma and urine by 2H NMR. Magnetic Resonance in Medicine, 45: 156–158. doi: 10.1002/1522-2594(200101)45:1<156::AID-MRM1020>3.0.CO;2-Z
Publication History
- Issue published online: 2 JAN 2001
- Article first published online: 2 JAN 2001
- Manuscript Accepted: 20 JUL 2000
- Manuscript Revised: 30 JUN 2000
- Manuscript Received: 29 MAR 2000
- Abstract
- Article
- References
- Cited By
Keywords:
- body water;
- deuterium;
- gluconeogenesis;
- tracer;
- biosynthetic pathways
Abstract
A simple and sensitive 2H NMR measurement of 2H2O enrichment from a 10 μl volume of body fluid is presented. The method allows 2H-enrichment levels of 0.1% or above to be rapidly determined from 10 μl of plasma or urine. The measurement is insensitive to the presence of plasma protein, allowing direct analysis of 2H2O enrichment from native plasma samples. Magn Reson Med 45:156–158, 2001. © 2001 Wiley-Liss, Inc.