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Keywords:

  • diabetes mellitus;
  • type 2 diabetes;
  • menopause;
  • HRT;
  • coronary artery disease

Abstract

Post‒menopausal type 2 diabetic patients are at enormous risk of increased mortality and morbidity from coronary artery disease (CAD). Attempts to modify contributory risk factors are likely to be only partially successful, and any other beneficial strategy should be vigorously adopted. Such a potential strategy is hormone (oestrogen) replacement therapy (HRT). Though a prospective randomised controlled trial of HRT for CAD primary prevention in type 2 diabetic females is lacking, there is considerable supportive evidence for its use, particularly of modern preparations. HRT should be seriously considered as a preventive strategy in this very high risk group of patients. Copyright © 2000 John Wiley & Sons, Ltd.