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Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: A longitudinal study

  1. Nancy E. Lane1,*,
  2. L. Robert Gore1,
  3. Steven R. Cummings1,
  4. Marc C. Hochberg2,
  5. Jean C. Scott3,
  6. Elizabeth N. Williams1,
  7. Michael C. Nevitt1

Article first published online: 22 MAR 2001

DOI: 10.1002/1529-0131(199905)42:5<854::AID-ANR3>3.0.CO;2-I

Issue

Arthritis & Rheumatism

Arthritis & Rheumatism

Volume 42, Issue 5, pages 854–860, May 1999

Additional Information

How to Cite

Lane, N. E., Gore, L. R., Cummings, S. R., Hochberg, M. C., Scott, J. C., Williams, E. N. and Nevitt, M. C. (1999), Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: A longitudinal study. Arthritis & Rheumatism, 42: 854–860. doi: 10.1002/1529-0131(199905)42:5<854::AID-ANR3>3.0.CO;2-I

Author Information

  1. 1

    University of California, San Francisco

  2. 2

    University of Maryland School of Medicine, and Department of Veterans Affairs Maryland Health Care System, Baltimore

  3. 3

    University of Maryland School of Medicine, Baltimore

*Division of Rheumatology, Box 0868, University of California, San Francisco, San Francisco, CA 94143

Publication History

  1. Issue published online: 22 MAR 2001
  2. Article first published online: 22 MAR 2001
  3. Manuscript Accepted: 29 DEC 1998
  4. Manuscript Received: 24 JUL 1998

Funded by

  • NIH. Grant Numbers: 1-R01-AR40431, 1-R01-AG05407
  • Rosalind Russell Arthritis Center

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Abstract

Objective

The purpose of this study was to determine the relationship of serum levels of 25-vitamin D and 1,25-vitamin D to incident changes of radiographic hip osteoarthritis (OA) among elderly white women.

Methods

Baseline and followup hip radiographs of 237 subjects were obtained an average of 8 years apart. Hips were scored for individual radiographic features (IRF) and assigned a summary grade based on the number and type of IRF present. Serum 25- and 1,25-vitamin D levels from baseline samples were analyzed by radioimmunoassay. Logistic and linear regression were used to examine the association of 25- and 1,25-vitamin D levels with radiographic changes, adjusting for age, health status, physical activity, weight, vitamin D supplement use, and calcaneal bone mineral density.

Results

The risk of incident hip OA defined as the development of definite joint space narrowing was increased for subjects who were in the middle (odds ratio [OR] 3.21, 95% confidence interval [95% CI] 1.06, 9.68) and lowest (OR 3.34, 95% CI 1.13, 9.86) tertiles for 25-vitamin D compared with subjects in the highest tertile. Vitamin D levels were not associated with incident hip OA defined as the development of definite osteophytes or new disease according to the summary grade. No association between serum 1,25-vitamin D and changes in radiographic hip OA was found.

Conclusion

Low serum levels of 25-vitamin D may be associated with incident changes of radiographic hip OA characterized by joint space narrowing.

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