Localization of a gene for familial recurrent arthritis
Article first published online: 26 MAR 2001
Copyright © 2000 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 43, Issue 9, pages 2041–2045, September 2000
How to Cite
Wise, C. A., Bennett, L. B., Pascual, V., Gillum, J. D. and Bowcock, A. M. (2000), Localization of a gene for familial recurrent arthritis. Arthritis & Rheumatism, 43: 2041–2045. doi: 10.1002/1529-0131(200009)43:9<2041::AID-ANR15>3.0.CO;2-G
- Issue published online: 26 MAR 2001
- Article first published online: 26 MAR 2001
- Manuscript Accepted: 1 MAY 2000
- Manuscript Received: 15 MAR 2000
- Texas Scottish Rite Hospital for Children
To localize the gene for familial recurrent arthritis via a genome-wide linkage scan in an extended kindred with the disease.
A 3-generation family in which 9 members were diagnosed with juvenile idiopathic arthritis (JIA) was ascertained. In this family the disease was of very early onset and included episodic inflammation leading to eventual destruction of joints, muscle, and skin. We treated this disorder as a distinct clinical entity that we have named “familial recurrent arthritis.” A genome-wide linkage scan with polymorphic microsatellites at 10–15-cM resolution was initiated.
The genome-wide scan generated a maximum 2-point logarithm of odds score with D15S211 (Zmax = 3.27 at θmax= 0.0010). Haplotype reconstruction defined a candidate region of ∼20 cM flanked proximally by D15S983 and distally by D15S127 on human chromosome 15.
A gene for familial recurrent arthritis was localized to 15q22-24, as a result of a genome-wide linkage scan in a large, multiply affected kindred. Identification of the altered gene will provide insights into the pathogenesis of autoimmune joint destruction that is reminiscent of JIA.