Brief Communication

Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging

  1. Susumu Mori PhD1,*,
  2. Barbara J. Crain MD, PhD2,
  3. V. P. Chacko PhD1,
  4. Peter C. M. Van Zijl PhD1

Article first published online: 31 MAY 2001

DOI: 10.1002/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3

Issue

Annals of Neurology

Annals of Neurology

Volume 45, Issue 2, pages 265–269, February 1999

Additional Information

How to Cite

Mori, S., Crain, B. J., Chacko, V. P. and Van Zijl, P. C. M. (1999), Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol., 45: 265–269. doi: 10.1002/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3

Author Information

  1. 1

    Department of Radiology, Division of MRI Research, Johns Hopkins Medical School, Baltimore, MD

  2. 2

    Department of Pathology, Johns Hopkins Medical School, Baltimore, MD

*217 Traylor, 720 Rutland Ave, Baltimore, MD 21205

Publication History

  1. Issue published online: 31 MAY 2001
  2. Article first published online: 31 MAY 2001
  3. Manuscript Accepted: 23 OCT 1998
  4. Manuscript Revised: 21 OCT 1998
  5. Manuscript Received: 17 AUG 1998

Funded by

  • Johns Hopkins School of Medicine
  • American Federation of Aging Research
  • Whitaker Foundation

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Abstract

The relationship between brain structure and complex behavior is governed by large-scale neurocognitive networks. The availability of a noninvasive technique that can visualize the neuronal projections connecting the functional centers should therefore provide new keys to the understanding of brain function. By using high-resolution three-dimensional diffusion magnetic resonance imaging and a newly designed tracking approach, we show that neuronal pathways in the rat brain can be probed in situ. The results are validated through comparison with known anatomical locations of such fibers. Ann Neurol 1999;45:265–269

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