GPi Firing rate modification during beginning-of-dose motor deterioration following acute administration of apomorphine

Authors

  • Marcelo Merello MD,

    Corresponding author
    1. Movement Disorders Section, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
    • Movement Disorders Section, Raul Carrea Institute for Neurological Research, FLENI, Montañeses 2323, (1428) Buenos Aires, Argentina
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  • Andrew J. Lees MD,

    1. The National Hospital for Neurology and Neurosurgery, Queen Square, London, U.K.
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  • Jorge Balej PhD,

    1. Movement Disorders Section, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
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  • Angel Cammarota MD,

    1. Movement Disorders Section, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
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  • Ramón Leiguarda MD

    1. Movement Disorders Section, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
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Abstract

We present a patient with clinically evident beginning-of-dose motor deterioration who had undergone posteroventral pallidotomy. This patient underwent an intrasurgical apomorphine test followed by single cell recording of the internal globus pallidus (GPi) to determine changes in GPi firing rate during the occurrence of such phenomenon. A significant increase in GPi firing rate coincident with worsening of patient disabilities prior to improvement was found. This finding suggests that beginning-of-dose motor deterioration may be mediated by enhanced thalamic inhibition.

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