The effect of pregnancy in Parkinson's disease

Authors

  • Lisa M. Shulman MD,

    Corresponding author
    1. Department of Neurology, University of Miami School of Medicine, Miami, Florida, U.S.A.
    • Department of Neurology, University of Miami School of Medicine, 1501 NW 9th Avenue, Miami, FL 33136, U.S.A.
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  • Alireza Minagar MD,

    1. Department of Neurology, University of Miami School of Medicine, Miami, Florida, U.S.A.
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  • William J. Weiner MD

    1. Department of Neurology, University of Miami School of Medicine, Miami, Florida, U.S.A.
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Abstract

Pregnancy in patients with Parkinson's disease (PD) is a rare occurrence. Previous reports based on retrospective analysis suggest that pregnancy may have a deleterious effect on PD. We describe the effects of pregnancy on the symptomatology of a 33-year-old woman with PD using quantitative neurologic and quality-of-life scales prepartum, intrapartum, and postpartum. During her pregnancy, she was only treated with carbidopa/levodopa. The pregnancy resulted in a normal full-term vaginal delivery of a healthy infant. Significant worsening of this patient's motor symptoms occurred during pregnancy without return to baseline at 15 months postpartum. Pregnancy may exacerbate PD and may have a long-term negative impact on the course of the illness. This report may assist physicians in the counseling of patients with young-onset PD who wish to consider pregnancy.

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