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Reagents & Catalysts
The Sharpless Asymmetric Aminohydroxylation –Scope and Limitation
Article first published online: 29 NOV 2002
DOI: 10.1002/1615-4169(200212)344:10<1169::AID-ADSC1169>3.0.CO;2-G
Copyright © 2002 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
1615-4169/asset/cover.gif?v=1&s=6b403eb4cdb02c56a05bd76afba87849efa73d61 "Advanced Synthesis & Catalysis")
Additional Information
How to Cite
Nilov, D. and Reiser, O. (2002), The Sharpless Asymmetric Aminohydroxylation –Scope and Limitation. Advanced Synthesis & Catalysis, 344: 1169–1173. doi: 10.1002/1615-4169(200212)344:10<1169::AID-ADSC1169>3.0.CO;2-G
Publication History
- Issue published online: 29 NOV 2002
- Article first published online: 29 NOV 2002
- Manuscript Received: 11 JUL 2002
- Abstract
- References
- Cited By
Keywords:
- amino alcohol;
- aminohydroxylation;
- asymmetric catalysis;
- dihydroxylation;
- osmium
Abstract
The asymmetric aminohydroxylation (AA) has emerged as a valuable tool in organic synthesis. Recent developments, such as ligandless variants, new nitrogen reagents and new substrates have considerably broadened the utility of the process. Nevertheless, the understanding of the AA, both in terms of mechanism as well as applicability to common synthetic tasks is still limited. This article summarizes the scope and limitation of the AA with special emphasis on recent advances.