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Research Article
Optimization and characterization of comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometric detection (GC×GC–TOF MS)
Article first published online: 13 MAR 2002
DOI: 10.1002/1615-9314(20020301)25:4<201::AID-JSSC201>3.0.CO;2-B
Copyright © 2002 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany
1615-9314/asset/cover.gif?v=1&s=4399e530f19bbe52b672f645b0757dc884404878 "Journal of Separation Science")
Additional Information
How to Cite
Dallüge, J., Vreuls, R. J. J., Beens, J. and Brinkman, U. A. Th. (2002), Optimization and characterization of comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometric detection (GC×GC–TOF MS). J. Sep. Science, 25: 201–214. doi: 10.1002/1615-9314(20020301)25:4<201::AID-JSSC201>3.0.CO;2-B
Publication History
- Issue published online: 13 MAR 2002
- Article first published online: 13 MAR 2002
- Manuscript Revised: 11 DEC 2001
- Manuscript Received: 18 SEP 2001
- Abstract
- References
- Cited By
Keywords:
- Comprehensive two-dimensional gas chromatography;
- GC×GC;
- Time-Of-flight mass spectrometry
Abstract
The influence of modulator temperature, modulation frequency, temperature programming rate, and carrier gas velocity on the performance of comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC×GC–TOF MS) was studied. The system was characterized with respect to the repeatability of peak areas and retention times of selected analytes, their detection limits, and the linearity of their calibration plots. The system was found to be linear in the 0.01–3 ng range, and detection limits for the pesticides were between 5 and 23 pg. The performance of the system was compared with that of conventional one-dimensional (1D) GC–TOF MS, the advantages of TOF MS for identification and deconvolution are discussed, and several approaches for the processing of GC×GC–TOF MS data are explained with the emphasis on (semi)-automated data processing and the differences with 1D-GC–TOF MS.