In this article a radial basis function (RBF) neural network improved by Gaussian mixture model is developed to be used for forecasting ionospheric 30 min total electron content (TEC) data given the merits of its nonlinear modeling capacity. In order to understand more about the response of developed network model with respect to stations situated at different latitude, estimated TEC overhead of GPS ground stations BJFS (39.61°N, 115.89°E), WUHN (30.53°N, 114.36°E), and KUNM (25.03°N, 102.80°E) for 6 months in 2011 are used for training data set, validating data and test data set of RBF network model. The performance of the trained model is evaluated at a set of criteria. Our results show that the predicted TEC is in good agreement with observations with mean relative error of about 9% and root-mean-square error of less than 5 total electron content unit, 1 TECU = 1016 el m−2. Our comparison further indicates that RBF network offers a powerful and reliable tool for the design of ionospheric TEC forecast.