Chapter 13. Regulation of the Cell Cycle

  1. Gerhard Krauss

Published Online: 17 DEC 2001

DOI: 10.1002/3527600051.ch13

Biochemistry of Signal Transduction and Regulation, Second Edition

Biochemistry of Signal Transduction and Regulation, Second Edition

How to Cite

Krauss, G. (2001) Regulation of the Cell Cycle, in Biochemistry of Signal Transduction and Regulation, Second Edition, Wiley-VCH Verlag GmbH, Weinheim, FRG. doi: 10.1002/3527600051.ch13

Author Information

  1. Laboratorium für Biochemie, Universität Bayreuth, D-95440 Bayreuth, Germany

Publication History

  1. Published Online: 17 DEC 2001
  2. Published Print: 17 JUL 2001

ISBN Information

Print ISBN: 9783527303786

Online ISBN: 9783527600052



  • cell cycle;
  • critical cell cycle events;
  • cell cycle transitions;
  • cyclin-dependent protein kinases (CDKs);
  • CDK activation;
  • CDK inactivation;
  • phosphorylation;
  • cyclins;
  • inhibitors of CDKs (CKIs);
  • proteolysis;
  • anaphase-promoting complex/cyclosome;
  • G1/S phase transition;
  • D type cyclins;
  • pRb;
  • G2/M transition;
  • Cdc25 phosphatase


  • Overview of the cell cycle

    • Principles of cell cycle control

    • Intrinsic control mechanisms

    • External control mechanisms

    • Critical cell cycle events and cell cycle transitions

  • Key elements of the cell cycle apparatus

    • Cyclin-dependent protein kinases, CDKs

    • Activation and inactivation of CDKs by phosphorylation

    • Cyclins

    • Stability of cyclins

    • Structural basis for CDK activation

    • Inhibitors of CDKs, the CKIs

    • Substrates of CDKs

    • Multiple regulation of CDKs

  • Regulation of the cell cycle by proteolysis

    • Targeted proteolysis at G1/S

    • Proteolysis during mitosis: the anaphase-promoting complex/cyclosome

  • The G1/S phase transition

    • Function of the D type cyclins

    • Function of pRb in the cell cycle

    • Model of pRb function

  • Cell cycle control of DNA replication

  • The G2/M transition and Cdc25 phosphatase

  • The DNA damage checkpoint