Chapter 2. The Regulation of Enzyme Activity

  1. Gerhard Krauss

Published Online: 17 DEC 2001

DOI: 10.1002/3527600051.ch2

Biochemistry of Signal Transduction and Regulation, Second Edition

Biochemistry of Signal Transduction and Regulation, Second Edition

How to Cite

Krauss, G. (2001) The Regulation of Enzyme Activity, in Biochemistry of Signal Transduction and Regulation, Second Edition, Wiley-VCH Verlag GmbH, Weinheim, FRG. doi: 10.1002/3527600051.ch2

Author Information

  1. Laboratorium für Biochemie, Universität Bayreuth, D-95440 Bayreuth, Germany

Publication History

  1. Published Online: 17 DEC 2001
  2. Published Print: 17 JUL 2001

ISBN Information

Print ISBN: 9783527303786

Online ISBN: 9783527600052

SEARCH

Keywords:

  • regulation of enzyme activity;
  • effector molecules;
  • allosteric regulation;
  • phosphorylation;
  • proteolysis;
  • ubiquitin-proteasome pathway

Summary

  • Enzymes as catalysts

  • Regulation of enzymes by effector molecules

  • Mechanistic descriptions of allosteric regulation

  • Structural basis of allosteric regulation on the example of phosphofructokinase

  • Regulation of enzyme activity by binding of inhibitor and activator proteins

  • Regulation of enzyme activity by phosphorylation

    • Regulation of glycogen phosphorylase by phosphorylation

    • Regulation of isocitrate dehydrogenase (E. coli) by phosphorylation

  • Regulation of enzyme activity by proteolysis

    • Maturation of proteins via proteolysis

    • Specific degradation of proteins in the “ubiquitin-proteasome” pathway