Chapter 4. Signaling by Nuclear Receptors

  1. Gerhard Krauss

Published Online: 17 DEC 2001

DOI: 10.1002/3527600051.ch4

Biochemistry of Signal Transduction and Regulation, Second Edition

Biochemistry of Signal Transduction and Regulation, Second Edition

How to Cite

Krauss, G. (2001) Signaling by Nuclear Receptors, in Biochemistry of Signal Transduction and Regulation, Second Edition, Wiley-VCH Verlag GmbH, Weinheim, FRG. doi: 10.1002/3527600051.ch4

Author Information

  1. Laboratorium für Biochemie, Universität Bayreuth, D-95440 Bayreuth, Germany

Publication History

  1. Published Online: 17 DEC 2001
  2. Published Print: 17 JUL 2001

ISBN Information

Print ISBN: 9783527303786

Online ISBN: 9783527600052

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Keywords:

  • nuclear receptors;
  • DNA binding elements;
  • HREs;
  • binding domains of nuclear receptors;
  • transactivating elements;
  • cytoplasmic apo-receptor complexes;
  • transcription repression;
  • signaling by retinoids;
  • signaling by vitamin D3;
  • signaling by T3-hormone;
  • RXR-heterodimers

Summary

  • Ligands of nuclear receptors

  • Principles of signaling by nuclear receptors

  • Classification and structure of nuclear receptors

    • DNA binding elements of nuclear receptors, HREs

    • The DNA binding domain of nuclear receptors

    • HRE recognition and structure of the HRE-receptor complex

    • Ligand binding domains

    • Transactivating elements of the nuclear receptors

  • The signaling pathway of the steroid hormone receptors

    • Activation of the cytoplasmic apo-receptor complexes

    • DNA binding and transactivation

    • Transcription repression by steroid hormone receptors

    • Regulation of the receptor activity by phosphorylation: crosstalk

  • Signaling by retinoids, vitamin D3, and the T3-hormone

    • The structure of the HREs of RXR-heterodimers

    • Complexity of the interaction between HRE, receptor and hormone

    • Ligand binding, activation and corepression of the RXR-heterodimers