Chapter 6. Intracellular Messenger Substances: “Second Messengers”

  1. Gerhard Krauss

Published Online: 17 DEC 2001

DOI: 10.1002/3527600051.ch6

Biochemistry of Signal Transduction and Regulation, Second Edition

Biochemistry of Signal Transduction and Regulation, Second Edition

How to Cite

Krauss, G. (2001) Intracellular Messenger Substances: “Second Messengers”, in Biochemistry of Signal Transduction and Regulation, Second Edition, Wiley-VCH Verlag GmbH, Weinheim, FRG. doi: 10.1002/3527600051.ch6

Author Information

  1. Laboratorium für Biochemie, Universität Bayreuth, D-95440 Bayreuth, Germany

Publication History

  1. Published Online: 17 DEC 2001
  2. Published Print: 17 JUL 2001

ISBN Information

Print ISBN: 9783527303786

Online ISBN: 9783527600052

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Keywords:

  • intracellular messenger substances;
  • cAMP;
  • cGMP;
  • inositol phospholipids;
  • inositol phosphate;
  • inositol 1,4,5-triphosphate;
  • Ca2+;
  • phosphatidyl inositol phosphate;
  • PI3-kinase;
  • PtdIns(3,4,5)P3;
  • PtdIns(4,5)P2;
  • calmodulin;
  • diacylglycerol;
  • NO signal molecule

Summary

  • General functions of intracellular messenger substances

  • cAMP

  • cGMP

  • Metabolism of inositol phospholipids and inositol phosphate

  • Inositol 1,4,5-triphosphate and release of Ca2+

    • Release of Ca2+ from Ca2+ storage

    • Influx of Ca2+ from the extracellular region

    • Removal and storage of Ca2+

    • Temporal and spatial changes in Ca2+ concentration

  • Phosphatidyl inositol phosphate and PI3-kinase

    • PI3-kinases

    • The messenger substance PtdIns(3,4,5)P3

    • Functions of PtdIns(4,5)P2

  • Ca2+ as a signal molecule

    • Calmodulin as a Ca2+ receptor

    • Target proteins of Ca2+/calmodulin

    • Other Ca2+ receptors

  • Diacylglycerol as a signal molecule

  • Other lipid messengers

  • The NO signal molecule

    • Reactivity and stability of NO

    • Synthesis of NO

    • Physiological functions and attack points of NO