Chapter 8. Signal Transmission via Transmembrane Receptors with Tyrosine-specific Protein Kinase Activity

  1. Gerhard Krauss

Published Online: 17 DEC 2001

DOI: 10.1002/3527600051.ch8

Biochemistry of Signal Transduction and Regulation, Second Edition

Biochemistry of Signal Transduction and Regulation, Second Edition

How to Cite

Krauss, G. (2001) Signal Transmission via Transmembrane Receptors with Tyrosine-specific Protein Kinase Activity, in Biochemistry of Signal Transduction and Regulation, Second Edition, Wiley-VCH Verlag GmbH, Weinheim, FRG. doi: 10.1002/3527600051.ch8

Author Information

  1. Laboratorium für Biochemie, Universität Bayreuth, D-95440 Bayreuth, Germany

Publication History

  1. Published Online: 17 DEC 2001
  2. Published Print: 17 JUL 2001

ISBN Information

Print ISBN: 9783527303786

Online ISBN: 9783527600052

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Keywords:

  • receptor tyrosine kinases;
  • effector proteins;
  • SH2 domains;
  • phosphotyrosine binding domain;
  • PTB domain;
  • SH3 domains;
  • pleckstrin homology domains;
  • PDZ domains;
  • WW domains;
  • nonreceptor tyrosine-specific protein kinases;
  • Src tyrosine kinase;
  • Abl tyrosine kinase;
  • protein tyrosine phosphatases

Summary

  • Structure and function of receptor tyrosine kinases

    • General structure and classification

    • Ligand binding and activation

    • Structure and activation of the tyrosine kinase domain

    • Effector proteins of the receptor tyrosine kinases

  • Protein modules as coupling elements of signal proteins

    • SH2 domains

    • Phosphotyrosine binding domain, PTB domain

    • SH3 domains

    • Pleckstrin homology domains

    • PDZ domains

    • WW domains

  • Nonreceptor tyrosine-specific protein kinases

    • Structure and general function of nonreceptor tyrosine kinases

    • Src tyrosine kinase and Abl tyrosine kinase

  • Protein tyrosine phosphatases

    • Structure and classification of protein tyrosine phosphatases

    • Cooperation of protein tyrosine phosphatases and protein tyrosine kinases

    • Regulation of protein tyrosine phosphatases

  • Adaptor molecules of intracellular signal transduction