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4,4′-Methylene diphenyl diisocyanate (MDI) [101-68-8] and “polymeric” MDI (PMDI) [9016-87-9] [MAK Value Documentation, 2008]

Documentations and Methods

Published Online: 21 APR 2015

DOI: 10.1002/3527600418.mb10168stae4515

Book Title

The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

Additional Information

How to Cite

2015. 4,4′-Methylene diphenyl diisocyanate (MDI) [101-68-8] and “polymeric” MDI (PMDI) [9016-87-9] [MAK Value Documentation, 2008] . The MAK Collection for Occupational Health and Safety. 1–52.

Publication History

  1. Published Online: 21 APR 2015
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Abstract

The article contains sections titled:

  • Toxic Effects and Mode of Action
  • Mechanism of Action
  • Toxicokinetics and Metabolism
    • Absorption, distribution, elimination
    • Metabolism
    • Binding to macromolecules/biological monitoring
  • Effects in Humans
    • Single exposures
    • Repeated exposure
    • Local effects on skin and mucous membranes
    • Allergenic effects
    • Reproductive and developmental toxicity
    • Genotoxicity
    • Carcinogenicity
  • Animal Experiments and in vitro Studies
    • Acute toxicity
    • Subacute, subchronic and chronic toxicity
    • Local effects on skin and mucous membranes
    • Allergenic effects
    • Reproductive toxicity
    • Genotoxicity
    • Carcinogenicity
  • Manifesto (MAK value, classification)

Keywords:

  • 4,4′-Methylene diphenyl diisocyanate;
  • MDI;
  • PMDI;
  • bis(p-isocyanatophenyl)methane;
  • bis(1,4-isocyanatophenyl)methane;
  • p,p'-diisocyanatodiphenylmethane;
  • 4,4'-diisocyanatodiphenylmethane;
  • diphenylmethane-p,p′-diisocyanate;
  • diphenylmethane−4,4'-diisocyanate;
  • isocyanic acid methylene di-p- phenylene ester;
  • methylenebis(4-phenylene isocyanate);
  • methylenebis(p-phenylene isocyanate);
  • p,p′-methylenebis(phenyl isocyanate);
  • 4,4'-methylenebis(phenyl isocyanate);
  • methylene bisphenyl isocyanate;
  • p,p′-methylenediphenyl diisocyanate;
  • 4,4'-methylenediphenyl diisocyanate;
  • methylenedi-p-phenylene diisocyanate;
  • methylenedi-4-phenylene diisocyanate;
  • 4,4'-methylenediphenylene isocyanate;
  • methylene di(phenylene isocyanate);
  • mechanism of action;
  • toxicokinetics;
  • metabolism;
  • (sub)acute toxicity;
  • (sub)chronic toxicity;
  • irritation;
  • allergenic effects;
  • reproductive toxicity;
  • fertility;
  • developmental toxicity;
  • genotoxicity;
  • carcinogenicity;
  • occupational exposure;
  • maximum workplace concentration;
  • MAK value;
  • toxicity;
  • hazardous substance
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