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1-Dodecanol [MAK Value Documentation, 2006]

Documentations and Methods

Published Online: 31 JAN 2012

DOI: 10.1002/3527600418.mb11253kske0022

The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

How to Cite

2012. 1-Dodecanol [MAK Value Documentation, 2006]. The MAK Collection for Occupational Health and Safety. 117–132.

Publication History

  1. Published Online: 31 JAN 2012


  1. References
  • Ando K, Kodama K, Kato A, Tamura G, Arima K (1972) Antitumor activity of glyceryl ethers. Cancer Res 32: 125129
  • Auth R, Pevny I, Peter G (1984) Ein Beitrag zur Wollwachsalkohol-Allergie (A contribution to wool wax alcohol allergy) (German). Aktuel Dermatol 10: 215220
  • Bartek J, LaBudde JA, Maibach HI (1972) Skin permeability in vivo: Comparison in rat, rabbit, pig and man. J Invest Dermatol 58: 114123
  • Basketter DA, Chamberlain M, Griffiths HA, Rowson M, Whittle E, York M (1997) The classification of skin irritants by human patch test. Food Chem Toxicol 35: 845852
  • Benane SG, Richard AM, Blackman CF, Lytle CD (1993) Quantitative structure-activity relationships for a series of primary aliphatic alcohols in a mammalian viral host cell reactivation assay. In vitro Toxicol 6: 267277
  • Bingham EL, Falk HL (1969) Environmental carcinogens: the modifying effect of cocarcinogens on the threshold response. Arch Environ Health 19: 779783
  • Danish National Food Agency (1992) Combined repeated dose and reproductive/developmental toxicity screening test in rats. Danish National Food Agency, IT 9211105, 19th August 1992
  • ECB (European Chemicals Bureau) (1998) IUCLID data sheet 1-Dodecanol. ECB, Ispra, Italy Egan RR, Portwood O (1974) Higher alcohols in skin lotions. Cosmet Perfum 89: 3942
  • Förster Th, von Rybinski W, Schwuger MJ (1988) Zur Wirkungsweise amphiphiler Korrosions-inhibitoren in Rostschutzemulsionen (The mode of action of amphiphilic corrosion inhibitors in antirust emulsions) (German). Ber Bunsenges Phys Chem 92: 10791083
  • Frosch PJ, Kligman AM (1976) The chamber-scarification test for irritancy. Contact Dermatitis 2: 314324
  • Frosch PJ, Kligman AM (1977) The chamber-scarification test for assessing irritancy of topically applied substances. in: Drill VA, Lazar P (Eds) Cutaneous toxicity – Proceedings of the 3rd conference on cutaneous toxicity 1976, Academic Press, New York, 127154
  • Gerarde HW, Ahlstrom DB (1966) The aspiration hazard and toxicity of a homologous series of alcohols. Arch Environ Health 13: 457461
  • Gilbert JP, Sicé J (1960) Dose-response relationship of a tumor-promoting agent. Toxicol Appl Pharmacol 2: 392396
  • Henkel (1980) Toxikologische Untersuchungen. Lorol spezial (Type 70) (Toxicological studies, Lorol spezial (Type 70)) (German). Archive No. TBD 800119, Henkel KGaA, Düsseldorf, 26th March 1980, unpublished
  • Henkel (1981a) Lorol C 12. Prüfung der akuten oralen Toxizität (Lorol C 12. Evaluation of acute toxicity) (German). Archive No. R 9500185 and Archive No. 930, Henkel KGaA, Düsseldorf, November 1981, unpublished
  • Henkel (1981b) Toxikologische Untersuchungen (Toxicological studies) (German). Archive No. TBD 810149, Henkel KGaA, Düsseldorf, 5th June 1981, unpublished
  • Henkel (1982) Ames-Test mit Lorol C 12. Prüfung auf Mutagenität in vitro (Ames test with Lorol C 12. Evaluation of mutagenicity in vitro) (German). Test report No. 295, Archive No. TBD 820115, Henkel KGaA, Düsseldorf, April 1982, unpublished
  • Henkel (1988) Prüfung der primären Schleimhautirritation am Kaninchenauge (Evaluation of primary mucous membrane irritation in the rabbit eye) (German). Report No. 880614, Henkel KGaA, Düsseldorf, 20th September 1988, unpublished
  • Henkel (1992) 1-Dodecanol (Lorol C12–99). Micronucleus test in vivo in the bone marrow cells of the mouse, Archive No. RT 920162, Henkel KGaA, Düsseldorf, 7th May 1992, unpublished
  • Henkel (1996) Lorol C 12–98; MV830, unverdünnt. 4 h Patch Test (in Anlehnung an OECD Guideline Nr. 404) (Lorol C 12–98, MV830, undiluted. 4 h patch test (in accordance with OECD Guideline No. 404)) (German). R 9601427, Henkel KGaA, Düsseldorf, September 1996, unpublished
  • Henkel (1999) 1-Dodecanol. Written communication from 15th November 1999
  • Hjorth N, Trolle-Lassen C (1963) Skin reactions to ointment bases. Trans St John's Hosp Dermatol Soc 49: 127140
  • Hopf G (1971) Empfehlungen für Hautverträglichkeitsprüfungen von Körperpflegemitteln (kosmetische Erzeugnisse) (Recommendations for evaluating the skin tolerance of toiletries (cosmetic products) (German). Fette Seifen Anstrichmittel 73: 467469
  • Ishiguro N, Kawashima M (1991) Contact dermatitis from impurities in alcohol. Contact Dermatitis 25: 257
  • Iwata Y, Moriya Y, Kobayashi T (1987) Percutaneous absorption of aliphatic compounds. Cosmet Toilet 102: 5368
  • Jaworska JS, Schultz TW (1993) Quantitative relationships of structure-activity and volume fraction for selected nonpolar and polar narcotic chemicals. SAR QSAR Environ Res 1: 319
  • Kästner W (1977) Zur Speziesabhängigkeit der Hautverträglichkeit von Kosmetikgrundstoffen (Skin tolerance of cosmetic ingredients varies with species) (German). J Soc Cosmet Chem 28: 741754
  • Kligman AM (1966) The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers. J Invest Dermatol 47: 393409 Kligman AM (1998) The myth of lanolin allergy. Contact Dermatitis 39: 103–107
  • Komamura H, Doi T, Inui S, Yoshikawa K (1997) A case of contact dermatitis due to impurities of cetyl alcohol. Contact Dermatitis 36: 4446
  • Lington AW, Bevan C (1994) Alcohols. in: Clayton GD, Clayton FE (Eds) Patty's industrial hygiene and toxicology, Vol. II D, John Wiley & Sons, New York, 25852760
  • Lipnick RL, Johnson DE, Gilford JH, Bickings CK, Newsome LD (1985) Comparison of fish toxicity screening data for 55 alcohols with the quantitative structure-relationship predictions of minimum toxicity for nonreactive nonelectrolyte organic compounds. Environ Toxicol Chem 4: 281296
  • Maibach H, Akerson J, Marzulli F, Wenninger J, Greif W, Hjorth N, Andersen KE, Wilkinson DS (1980) Test concentrations and vehicles for dermatological testing of cosmetic ingredients. Contact Dermatitis 6: 369404
  • McCreery MJ, Hunt WA (1978) Physico-chemical correlates of alcohol intoxication. Neuropharmacology 17: 451461
  • Miura Y (1981) Omega- and (omega-1)-hydroxylation of 1-dodecanol by frog liver microsomes. Lipids 16: 721725
  • Motoyoshi K, Toyoshima Y, Sato M, Yoshimura M (1979) Comparative studies on the irritancy of oils and synthetic perfumes to the skin of rabbit, guinea pig, rat, miniature swine and man. Cosmet Toilet 94: 4148
  • Nishiyama T, Iwata Y, Nakajima K, Mitsui T (1983) In vivo percutaneous absorption of polyoxyethylene lauryl ether surfactants in hairless mice. J Soc Cosmet Chem 34: 263271
  • Noweck K, Ridder H (1987) Fatty alcohols. in: Gerhartz W, Yamamoto YS, Kaudy L (Eds) Ullmann's encyclopedia of industrial chemistry, Vol. A10. Ethanolamines to fibres, 4. Synthetic organic, VCH, Weinheim, 277296
  • Opdyke DL (1973a) Fragrance raw materials monographs. Alcohol C-12. Food Cosmet Toxicol 11 Suppl: 109
  • Opdyke DL (1973b) Fragrance raw materials monographs. Alcohol C-12. Food Cosmet Toxicol 11 Suppl: 1080
  • Peter G, Schröpl F, Franzwa H (1969) Experimentelle Untersuchungen über die allergene Wirkung von Wollwachsalkoholen (Experimental studies on the allergic effect of wool wax alcohols) (German). Hautarzt 20: 450455
  • Phillips L II, Steinberg M, Maibach HI, Akers WA (1972) A comparison of rabbit and human skin response to certain irritants. Toxicol Appl Pharmacol 21: 369382
  • Procter & Gamble (1999) Review of biological studies on fatty alcohols, Procter & Gamble, 15th April 1999, unpublished
  • Rang HP (1960) Unspecific drug action. The effects of a homologous series of primary alcohols. Brit J Pharmacol 15: 185200
  • Rieger MM, Battista GW (1964) Some experiences in the safety testing of cosmetics. J Soc Cosmet Chem 15: 161172
  • Rietschel RL, Fowler Jr. JF (1995) Fisher's contact dermatitis, 4th ed., Williams & Wilkins, Baltimore, 1014
  • Rowe VK, McCollister SB (1982) Alcohols. in: Clayton GD, Clayton FE (Eds) Patty's industrial hygiene and toxicology, 3rd ed., Vol. 2C, John Wiley & Sons, New York, 46324634
  • Sato A, Obata K, Ikeda Y, Ohkoshi K, Okumura H, Ozawa N, Ogawa T, Katsumura Y, Kawai J, Tatsumi H, Honoki S, Hiramatsu I, Hiroyama H, Okada T, Kozuka T (1996) Evaluation of human skin irritation by carboxylic acids, alcohols, esters and aldehydes, with nitrocellulose-replica method and closed patch testing. Contact Dermatitis 34: 1216
  • Shimizu H, Suzuki Y, Takemura N, Goto S, Matsushita H (1985) The results of microbial mutation test for forty-three industrial chemicals. Jpn J Ind Health 27: 400419
  • Sicé J (1966) Tumor-promoting activity of n-alkanes and n-alkanols. Toxicol Appl Pharmacol 9: 7074
  • Stoner GD, Shimkin MB, Kniazeff AJ, Weisburger JH, Weisburger EK, Gori GB (1973) Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice. Cancer Res 33: 30693085
  • Tosti A, Vincenzi C, Guerra L, Andrisano E (1996) Contact dermatitis from fatty alcohols. Contact Dermatitis 35: 287289
  • Treon JF (1963) Alcohols. in: Patty FA (Ed.) Industrial hygiene and toxicology, 2nd ed., Vol. 2, Toxicology, John Wiley & Sons, New York, 14681469
  • Ulrich C, Marold W (1979) Pulmonary deposition of aerosols in individual and group caged rats. Am Ind Hyg Assoc J 40: 633636
  • Van Duuren BL, Goldschmidt BM (1976) Cocarcinogenic and tumor-promoting agents in tobacco carcinogenesis. J Natl Cancer Inst 56: 12371242
  • Wakabayashi T, Adachi K, Popinigis J (1991) Effects of alkyl alcohols and related chemicals on rat liver structure and function. Acta Pathol Jpn 41: 405413
  • Williams RT (1959) Detoxication mechanisms. The metabolism and detoxication of drugs, toxic substances and other organic compounds, Chapman & Hall, London, 4687
  • Yoshida M, Ikumo H, Suzuki O (1971) Evaluation of available energy of aliphatic chemicals by rats. An application of bioassay of energy to mono-gastric animals. Agric Biol Chem 35: 12081215