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Isoprene (2-methyl-1,3-butadiene) [MAK Value Documentation, 2009]

Documentations and Methods

Published Online: 25 NOV 2015

DOI: 10.1002/3527600418.mb7879e4615

Book Title

The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

Additional Information

How to Cite

2015. Isoprene (2-methyl-1,3-butadiene) [MAK Value Documentation, 2009] . The MAK Collection for Occupational Health and Safety. 1–58.

Publication History

  1. Published Online: 25 NOV 2015
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Abstract

The article contains sections titled:

  • Toxic Effects and Mode of Action
  • Mechanism of Action
  • Toxicokinetics and Metabolism
    • Endogenous formation of isoprene
    • Absorption, distribution, elimination
    • Metabolism
    • Haemoglobin adduct formation
    • Physiological toxicokinetic models
    • Derivation of a MAK value for isoprene
  • Effects in humans
    • Single exposures
    • Repeated exposure
    • Effects on skin and mucous membranes
    • Allergenic effects
    • Reproductive and developmental toxicity
    • Genotoxicity
    • Carcinogenicity
  • Animal experiments and in vitro studies
    • Acute toxicity
    • 5.2 Subacute, subchronic and chronic toxicity
    • Effects on skin and mucous membranes
    • Allergenic effect
    • Reproductive toxicity
    • Genotoxicity
    • Carcinogenicity
    • Other effects
  • Manifesto

Keywords:

  • isoprene;
  • hemiterpene;
  • isopentadiene;
  • beta-methylbivinyl;
  • 2-methylbutadiene;
  • mechanism of action;
  • toxicokinetics;
  • metabolism;
  • (sub)acute toxicity;
  • (sub)chronic toxicity;
  • irritation;
  • reproductive toxicity;
  • fertility;
  • developmental toxicity;
  • genotoxicity;
  • carcinogenicity;
  • occupational exposure;
  • maximum workplace concentration;
  • MAK value;
  • toxicity;
  • hazardous substance
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