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Biosimulation and Computations in Systems Biology

  1. Olga Sosnovtseva,
  2. Jakob L. Laugesen,
  3. Erik Mosekilde

Published Online: 15 AUG 2009

DOI: 10.1002/3527600434.eap678

Encyclopedia of Applied Physics

Encyclopedia of Applied Physics

How to Cite

Sosnovtseva, O., Laugesen, J. L. and Mosekilde, E. 2009. Biosimulation and Computations in Systems Biology. Encyclopedia of Applied Physics. .

Author Information

  1. Technical University of Denmark, Department of Physics, Lyngby, Denmark

Publication History

  1. Published Online: 15 AUG 2009


We give an overview of the physical basics, experimental techniques, and selected applications of single molecule fluorescence in biophysical research. The photophysical principles underlying single molecule fluorescence resonance energy transfer (smFRET) experiments are treated. Its application in protein biophysics, in particular protein folding and conformational dynamics associated with enzymatic activity, is outlined with selected model systems.


  • GFR;
  • GnRH;
  • LH;
  • macula densa;
  • TGF