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Raman Spectroscopy in Medicine

  1. Christoph Krafft1,
  2. Petra Rösch2,
  3. Jürgen Popp1,2

Published Online: 15 AUG 2009

DOI: 10.1002/3527600434.eap680

Encyclopedia of Applied Physics

Encyclopedia of Applied Physics

How to Cite

Krafft, C., Rösch, P. and Popp, J. 2009. Raman Spectroscopy in Medicine. Encyclopedia of Applied Physics. .

Author Information

  1. 1

    Institute of Photonic Technology, Jena, Germany

  2. 2

    Institute of Physical Chemistry, Friedrich-Schiller-University Jena, Jena, Germany

Publication History

  1. Published Online: 15 AUG 2009

Abstract

Raman spectroscopy is an emerging tool in medicine to study tissues and body fluids. This contribution gives an overview of experimental techniques and selected applications. The methodological section presents Raman spectra of biomolecules, the near-infrared advantage, combination with microscopy, Raman imaging, fiber-optic probes, and signal enhancement principles. Pathological applications of Raman spectroscopy were reported in the context of oncology, for mineralized tissue such as bone, teeth, and calculi in organs, for blood vessels, for skin, and for the visual system. Raman spectroscopy in clinical chemistry was applied to determine glucose in diabetic patients; to analyze serum, hair and nails; and to investigate malaria.

Keywords:

  • Raman imaging;
  • fiber-optic probe;
  • Raman spectroscopy;
  • Raman spectra;
  • Raman microscopy