Chapter 9. Scalar Couplings across Hydrogen Bonds†

  1. Dr. Oliver Zerbe
  1. Andrew J. Dingley1,
  2. Florence Cordier2,
  3. Victor A. Jaravine2,
  4. Stephan Grzesiek2

Published Online: 4 MAR 2003

DOI: 10.1002/3527600663.ch9

Book Title

BioNMR in Drug Research, Volume 16

BioNMR in Drug Research, Volume 16

Additional Information

How to Cite

Dingley, A. J., Cordier, F., Jaravine, V. A. and Grzesiek, S. (2003) Scalar Couplings across Hydrogen Bonds, in BioNMR in Drug Research, Volume 16 (ed O. Zerbe), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527600663.ch9

Editor Information

  1. Institute of Pharmaceutical Sciences, Department of Applied Biosciences, ETH Zürich, Winterthurer Str. 190, CH-8057 Zürich, Switzerland

Author Information

  1. 1

    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom

  2. 2

    Division of Structural Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland

  1. †

    This chapter is an updated version of an article previously published as “Scalar couplings across hydrogen bonds” by S. Grzesiek, F. Cordier, and A. J. Dingley, Methods in Enzymology 2001, 338, 111–133. Reprinted by permission of the publisher.

Publication History

  1. Published Online: 4 MAR 2003
  2. Published Print: 7 NOV 2002

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold4,
  2. Prof. Dr. Hugo Kubinyi5,
  3. Prof. Dr. Gerd Folkers3

Series Editor Information

  1. 3

    Institute of Pharmaceutical Sciences, Department of Applied Biosciences, ETH Zürich, Winterthurer Str. 190, CH-8057 Zürich, Switzerland

  2. 4

    Biomedical Research Center, Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstraße 1, 40225 Düsseldorf, Germany

  3. 5

    BASF AG Ludwigshafen, c/o Donnersbergstraße 9, 67256 Weisenheim am Sand, Germany

ISBN Information

Print ISBN: 9783527304653

Online ISBN: 9783527600663

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CHAPTER TOOLS

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Keywords:

  • scalar couplings;
  • hydrogen bonds;
  • biomacromolecules;
  • nucleic acids;
  • proteins;
  • protein-nucleic acid complexes;
  • chemical shift;
  • geometry;
  • H-bond lengths;
  • H-bond angles;
  • applications;
  • secondary structure;
  • tertiary structure;
  • protein folding

Summary

This chapter contains sections titled:

  • Introduction

  • H-Bond Scalar Couplings in Biomacromolecules

    • Nucleic Acids

    • Proteins

    • Protein-Nucleic Acid Complexes

  • Relation to Chemical Shift

  • Dependence on Geometry

    • H-Bond Lengths

    • H-Bond Angles

  • Applications

    • Establishment of Secondary and Tertiary Sructure Information

    • Physicochemically-Induced Changes in H-Bond Geometry

    • Ligand-Induced Changes in H-Bond Geometry

    • Protein Folding

  • Conclusions

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