Antibody Molecules, Genetic Engineering of
Published Online: 15 SEP 2006
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA. All rights reserved.
Reviews in Cell Biology and Molecular Medicine
How to Cite
Penichet, M. L. and Morrison, S. L. 2006. Antibody Molecules, Genetic Engineering of. Reviews in Cell Biology and Molecular Medicine. .
- Published Online: 15 SEP 2006
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Antibodies have long been appreciated for their exquisite specificity. With the development of the hybridoma technology, it was possible to produce rodent (mouse or rat) monoclonal antibodies that are the product of a single clone of antibody-producing cells and have only one antigen-binding specificity. Advances in genetic engineering and expression systems have been applied to overcome problems of immunogenicity of rodent-produced antibodies and to improve their ability to trigger human immune effector mechanisms. The production of chimeric, humanized, and totally human antibodies as well as antibodies with novel structures and functional properties has resulted in improved monoclonal antibodies. As a consequence, recombinant antibody-based therapies are now used to treat a variety of diverse conditions that include infectious diseases, inflammatory disorders, and cancer. This article summarizes and compares different strategies for developing recombinant antibodies and their derivatives.
- Antibody-dependent Cellular Cytotoxicity (ADCC);
- Constant Region;
- Variable Region