Autoimmunity in Scleroderma
Published Online: 15 SEP 2006
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA
Encyclopedia of Molecular Cell Biology and Molecular Medicine
How to Cite
Muro, Y. and Sugimoto, K. 2006. Autoimmunity in Scleroderma. Encyclopedia of Molecular Cell Biology and Molecular Medicine.
- Published Online: 15 SEP 2006
Scleroderma is a multisystem connective tissue disease of unknown etiology characterized by abnormal deposition of collagen in the skin and internal organs, and microvascular obliteration. Several autoantibodies against cellular components are striking features of scleroderma and some are associated with certain clinical subsets. This article mainly reviews the autoimmune phenomenon against centromere antigens and topoisomerase-I, which are commonly found in the limited skin sclerosis type and the proximal type respectively. For the production of autoantibodies, molecular mimicry hypothesis and implications of apoptosis are also discussed.
- Anticentromere Antibodies;
- Antitopoisomerase I Antibodies;
- Recombinant Protein;