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Autoimmunity in Scleroderma

Molecular Biology of Specific Diseases

  1. Yoshinao Muro1,
  2. Kenji Sugimoto2

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200300004

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Muro, Y. and Sugimoto, K. 2006. Autoimmunity in Scleroderma. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. 1

    Nagoya Graduate University School of Medicine, Nagoya, Japan

  2. 2

    Osaka Prefecture University, Sakai, Osaka, Japan

Publication History

  1. Published Online: 15 SEP 2006


Scleroderma is a multisystem connective tissue disease of unknown etiology characterized by abnormal deposition of collagen in the skin and internal organs, and microvascular obliteration. Several autoantibodies against cellular components are striking features of scleroderma and some are associated with certain clinical subsets. This article mainly reviews the autoimmune phenomenon against centromere antigens and topoisomerase-I, which are commonly found in the limited skin sclerosis type and the proximal type respectively. For the production of autoantibodies, molecular mimicry hypothesis and implications of apoptosis are also discussed.


  • Anticentromere Antibodies;
  • Antitopoisomerase I Antibodies;
  • Epitope;
  • Recombinant Protein;
  • Scleroderma