Standard Article

Biotransformations of Drugs and Chemicals

Pharmacology

  1. Paul R. Ortiz de Montellano

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200300009

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Ortiz de Montellano, P. R. 2006. Biotransformations of Drugs and Chemicals. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. University of California, Department of Pharmaceutical Chemistry, San Francisco, CA, USA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Drug and xenobiotic metabolism converts the lipophilic compounds that can be absorbed into the body into polar, excretable products, thus preventing their accumulation, but also sometimes forms more toxic products.

Keywords:

  • Electrophilic;
  • Endobiotic;
  • LogP;
  • Nucleophilic;
  • Prodrug;
  • Xenobiotic