Molecular Genetics of Genomic Imprinting
Published Online: 10 OCT 2011
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Reviews in Cell Biology and Molecular Medicine
How to Cite
Hirasawa, R., Kota, S. K. and Feil, R. 2011. Molecular Genetics of Genomic Imprinting. Reviews in Cell Biology and Molecular Medicine. .
- Published Online: 10 OCT 2011
Genomic imprinting is a developmental mechanism in placental mammals leading to the repression or expression of genes, depending on whether they are inherited from the mother or the father. The imprinted expression of genes is regulated by various epigenetic alterations, including DNA methylation and covalent modifications on histones. A large number of imprinted genes have been identified. Mostly organized in gene clusters in the genome, imprinted genes play important roles in embryonic and extraembryonic development, and in behavior. In humans, genetic and epigenetic alterations at imprinted gene clusters are involved in different disease syndromes, and in cancer.
- Androgenetic embryo;
- DNA methylation;
- Gynogenetic embryo;
- Genomic imprinting;
- Histone modification;
- Imprinting and behavior;
- Imprinting and growth;
- Imprinting control regions (ICRs);
- Long noncoding RNAs;
- Primordial germ cells (PGCs);
- Uniparental disomy (UPD)