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Molecular Genetics of Genomic Imprinting

  1. Ryutaro Hirasawa,
  2. Satya K. Kota,
  3. Robert Feil

Published Online: 10 OCT 2011

DOI: 10.1002/3527600906.mcb.200300031.pub2

Encyclopedia of Molecular Cell Biology and Molecular Medicine

Encyclopedia of Molecular Cell Biology and Molecular Medicine

How to Cite

Hirasawa, R., Kota, S. K. and Feil, R. 2011. Molecular Genetics of Genomic Imprinting. Encyclopedia of Molecular Cell Biology and Molecular Medicine. .

Author Information

  1. Centre National de la Recherche Scientific and University of Montpellier, CNRS, UMR 5535, Institute of Molecular Genetics (IGMM), Montpellier, France

Publication History

  1. Published Online: 10 OCT 2011

Abstract

Genomic imprinting is a developmental mechanism in placental mammals leading to the repression or expression of genes, depending on whether they are inherited from the mother or the father. The imprinted expression of genes is regulated by various epigenetic alterations, including DNA methylation and covalent modifications on histones. A large number of imprinted genes have been identified. Mostly organized in gene clusters in the genome, imprinted genes play important roles in embryonic and extraembryonic development, and in behavior. In humans, genetic and epigenetic alterations at imprinted gene clusters are involved in different disease syndromes, and in cancer.

Keywords:

  • Androgenetic embryo;
  • Chromatin;
  • DNA methylation;
  • Gynogenetic embryo;
  • Genomic imprinting;
  • Histone modification;
  • Imprinting and behavior;
  • Imprinting and growth;
  • Imprinting control regions (ICRs);
  • Long noncoding RNAs;
  • Nucleosome;
  • Parthenogenesis;
  • Primordial germ cells (PGCs);
  • Uniparental disomy (UPD)