Standard Article

Genomic Imprinting, Molecular Genetics of

Nucleic Acids

  1. Robert Feil,
  2. Yuji Goto,
  3. David Umlauf

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200300031

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Feil, R., Goto, Y. and Umlauf, D. 2006. Genomic Imprinting, Molecular Genetics of. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. Centre National de la Recherche Scientifique, Montpellier, France

Publication History

  1. Published Online: 15 SEP 2006

This is not the most recent version of the article. View current version (10 OCT 2011)

Abstract

Genomic imprinting is a developmental mechanism in mammals and other organisms leading to repression or expression of genes depending on whether they are inherited from the mother or the father. The imprinted expression of genes is regulated by various epigenetic alterations, including DNA methylation and covalent modifications at histones. A large number of imprinted genes have been identified in placental mammals. Mostly clustered in the genome, these play important roles in embryonic and extraembryonic development, and in behavior. In humans, genetic and epigenetic alterations at imprinted genes are involved in different disease syndromes and in cancer.

Keywords:

  • Androgenetic Embryo;
  • Chromatin;
  • DNA Methylation;
  • Epigenetic Modification;
  • Genomic Imprinting;
  • Histone Modification;
  • Imprinting and Behavior;
  • Imprinting and Cancer;
  • Imprinting and Growth;
  • Imprinting-control Regions;
  • Nucleosome;
  • Nutrient Transfer;
  • Parthenogenesis;
  • Uniparental Disomy