Genomic Imprinting, Molecular Genetics of
Published Online: 15 SEP 2006
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA. All rights reserved.
Reviews in Cell Biology and Molecular Medicine
How to Cite
Feil, R., Goto, Y. and Umlauf, D. 2006. Genomic Imprinting, Molecular Genetics of. Reviews in Cell Biology and Molecular Medicine. .
- Published Online: 15 SEP 2006
This is not the most recent version of the article. View current version (10 OCT 2011)
Genomic imprinting is a developmental mechanism in mammals and other organisms leading to repression or expression of genes depending on whether they are inherited from the mother or the father. The imprinted expression of genes is regulated by various epigenetic alterations, including DNA methylation and covalent modifications at histones. A large number of imprinted genes have been identified in placental mammals. Mostly clustered in the genome, these play important roles in embryonic and extraembryonic development, and in behavior. In humans, genetic and epigenetic alterations at imprinted genes are involved in different disease syndromes and in cancer.
- Androgenetic Embryo;
- DNA Methylation;
- Epigenetic Modification;
- Genomic Imprinting;
- Histone Modification;
- Imprinting and Behavior;
- Imprinting and Cancer;
- Imprinting and Growth;
- Imprinting-control Regions;
- Nutrient Transfer;
- Uniparental Disomy