Standard Article

Dendritic Cells

Cell Biology

  1. Manfred B. Lutz,
  2. Thomas Berger,
  3. Erwin Schultz,
  4. Alexander Steinkasserer

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200300058

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Lutz, M. B., Berger, T., Schultz, E. and Steinkasserer, A. 2006. Dendritic Cells. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. University Hospital of Erlangen, Department of Dermatology, Erlangen, Germany

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Dendritic cells (DC) are the most potent antigen-presenting cells known today. They are the only antigen-presenting cells able to induce naïve T helper and cytotoxic T cells and are thus also known as natures adjuvant. In this review article, we will cover several aspects regarding the biological function of DC including antigen processing and presentation as well as antigen delivery systems including viral and non-viral systems. Specific chapters will focus on the function of DC as immunostimulators and as inductors of tolerance. A specific section will describe the interaction between DC and viruses including viral escape strategies. The final chapter will focus on the use of modified DC vaccines in the fight against cancer and virus-associated malignancies.

Keywords:

  • Clinical Studies;
  • Dendritic Cells;
  • Immunity;
  • Tolerance;
  • Tumor Vaccine;
  • Virus