Anthrax (Bacillus anthracis), Molecular Biology of
Published Online: 15 SEP 2006
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA
Encyclopedia of Molecular Cell Biology and Molecular Medicine
How to Cite
Garber, K. B. 2006. Anthrax (Bacillus anthracis), Molecular Biology of. Encyclopedia of Molecular Cell Biology and Molecular Medicine. .
- Published Online: 15 SEP 2006
Bacillus anthracis, the causative agent of anthrax, has been a subject of research for over 150 years, beginning with the work of Rayer and Davaine who found “small filiform bodies” in the blood of anthrax-infected sheep and, from this finding, coined the term bacteria. Several years later, Koch proved conclusively that B. anthracis was the causative agent of anthrax, providing the first demonstration that a disease was caused by a specific bacterium. He later developed the first live attenuated bacterial vaccine with a heat-attenuated strain of B. anthracis. Despite its illustrious beginnings as a subject of research, an understanding of the molecular biology of B. anthracis has lagged behind that of some other bacteria. Bacillus anthracis has recently come back into focus as a target of research with the goal of being able to readily detect this bacterium in environmental samples and to understand its pathogenesis and evolution better.
- Virulence Factor;