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Cellular Interactions

Cell Biology

  1. Brian A. Koeneman,
  2. David G. Capco

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200300099

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Koeneman, B. A. and Capco, D. G. 2006. Cellular Interactions. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. Arizona State University Tempe, School of Life Sciences Cellular and Molecular Biosciences Faculty, AZ, USA

Publication History

  1. Published Online: 15 SEP 2006


The developmental transition of fertilization is a major organizational and functional change, which initiates a rapid series of changes that restructures the egg into the zygote. A series of cytoplasmic signal transduction events mediate these changes after the sperm penetrates the egg, resulting in a rise in [Ca2+]i. The egg undergoes rapid structural changes that result in the extensive remodeling of this specialized cell. Two pivotal signaling agents that mediate several of these rapid modifications in cell structure are protein kinase C (PKC) and calcium/calmodulin-dependent protein kinase II (CaM KII). Studies indicate that elements from several of the key signaling pathways, including PKC and CaM KII, colocalize on molecular scaffolds (i.e. meiotic spindle) in the egg and may provide a means for these pathways to interact.


  • [Ca2+]i (Concentration of Intracellular-free Calcium);
  • CaM KII (Calcium/Calmodulin-dependent Protein Kinase II);
  • Cytoskeleton;
  • Egg Activation;
  • Signal Transduction;
  • MAP Kinase (Mitogen-activated Protein Kinase);
  • Molecular Scaffold;
  • PKC (Protein Kinase C)