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Genetic Engineering of Vaccines

Biotechnology

  1. Tilahun D. Yilma,
  2. Leslie A. Jones,
  3. Paulo H. Verardi

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200300108

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Yilma, T. D., Jones, L. A. and Verardi, P. H. 2006. Genetic Engineering of Vaccines. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. University of California, International Laboratory of Molecular Biology for Tropical Disease Agents, Davis, California

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Using the techniques of molecular biology, effective modern vaccines are being developed by a variety of innovative methods that circumvent some of the problems associated with conventional vaccines. Live recombinant vaccines, which are prepared by isolating an immunogenic gene(s) from a disease organism and inserting it into a vector, are most promising. Such vaccines can provide immunity to agents that cannot be reliably attenuated or inactivated without destroying immunogenicity and allow one to distinguish vaccinated from infected animals.

Keywords:

  • Adjuvant Genes;
  • Attenuating Genes;
  • Baculovirus;
  • Chimeric;
  • Recombinant;
  • Vaccinia Virus;
  • Vector