Standard Article

DNA Repair in Yeast

Molecular Biology of Specific Organisms

  1. Errol C. Friedberg,
  2. Paula L. Fischhaber

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200300112

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Friedberg, E. C. and Fischhaber, P. L. 2006. DNA Repair in Yeast. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. The University of Texas Southwestern Medical Center, Dallas, TX, USA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

DNA repair comprises a series of biochemical processes by which alterations of the chemical structure of DNA are eliminated and the DNA is restored to its native state. By strict definition, the term excludes cellular responses by which DNA damage is tolerated but not eliminated from the genome. However, popular usage has incorporated DNA damage tolerance as a mode of DNA repair in a biologically meaningful sense. Hence, for completeness, a particular mode of damage tolerance called translesion DNA synthesis (TLS) is included in this discussion.

DNA repair occurs by a variety of distinct biochemical pathways. These differ primarily on the basis of the particular type of damage under consideration. The damage can affect both, the nitrogenous bases and the sugar-phosphate backbone of DNA. The most important form of DNA damage in the latter category is strand breaks. However, this discussion is confined to the repair of damage to the nitrogenous bases in DNA, the informational components of the genetic material. The detailed mechanisms of known DNA repair pathways vary in different organisms. This article considers DNA repair pathways in the yeast, Saccharomyces cerevisiae .

Keywords:

  • Enzymatic Photoreactivation;
  • DNA Photolyase;
  • Cyclobutane Pyrimidine Dimers;
  • O6-Methylguanine-DNA Methyltransferase;
  • Base Excision Repair;
  • Nucleotide Excision Repair;
  • Mismatch Repair;
  • DNA Damage Tolerance