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Animal Biotechnology and Modeling


  1. Carl A. Pinkert,
  2. Michael H. Irwin,
  3. Robert L. Howell

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200300121

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Pinkert, C. A., Irwin, M. H. and Howell, R. L. 2006. Animal Biotechnology and Modeling. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA

Publication History

  1. Published Online: 15 SEP 2006


Transgenic animals and our ability to manipulate the genome of whole animals in vivo have influenced the life sciences in dramatic fashion. In less than 15 years, practical aspects of germ line manipulation of the genetic composition of animals have allowed researchers to address fundamental questions in fields ranging from medicine and biology to biotechnology and production agriculture. Studies emanating from basic efforts in gene regulation have led the way to in vivo gene-transfer studies focused on the expression of foreign genes and the ablation of endogenous genes. Our appreciation of basic biological development in animals and the potential ramifications of novel phenotypes resulting from genetic engineering efforts have been markedly influenced by pioneering efforts in transgenic animal technology.


  • DNA Microinjection;
  • Embryonic Stem (ES) Cell Transfer;
  • Gene Transfer;
  • Nuclear Transfer (Cloning);
  • Transgenic Animal;
  • Transgenic Founder;
  • Transgenic Line