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Gene Expression and Replication of Picornaviruses

Molecular Biology of Specific Diseases

  1. Christopher T. Cornell,
  2. Bert L. Semler

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200300167

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Cornell, C. T. and Semler, B. L. 2006. Gene Expression and Replication of Picornaviruses. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. University of California, Department of Microbiology and Molecular Genetics, College of Medicine, Irvine, CA, USA

Publication History

  1. Published Online: 15 SEP 2006


Picornaviruses are the agents responsible for numerous diseases of varying severities that affect the population of the world whose susceptible hosts include humans and other vertebrates. These viruses are presently classified into seven major genera and are responsible for diseases like paralytic poliomyelitis (poliovirus), myocarditis (coxsackievirus), the common cold (rhinovirus), hepatitis (hepatitis A virus), and foot-and-mouth disease (foot-and-mouth disease virus). Despite the ability of these viruses to cause a wide array of maladies, they all share common features among their replication and gene expression strategies, often allowing insights from studies on one virus to be applied to another. With the advent of powerful molecular biology techniques, picornaviruses have provided a wealth of information surrounding protein–protein and protein–RNA interactions that are critical for the process of viral replication and subversion of the host cell. Importantly, this has also furthered our understanding of eukaryotic gene expression and the regulation of other host cell processes.


  • Internal Ribosome Entry Site (IRES);
  • Noncoding Region (NCR);
  • RNA-dependent RNA Polymerase;
  • Proteinase;
  • Cap-independent Translation;
  • Polyprotein