Nucleic Acid Packaging of RNA Viruses
Molecular Biology of Specific Organisms
Published Online: 15 SEP 2006
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA. All rights reserved.
Reviews in Cell Biology and Molecular Medicine
How to Cite
Pirttimaa, M. J. and Bamford, D. H. 2006. Nucleic Acid Packaging of RNA Viruses. Reviews in Cell Biology and Molecular Medicine. .
- Published Online: 15 SEP 2006
Viruses are obligate intracellular parasites composed of virus-specific nucleic acid and a protective coat. During virus assembly, the critical stage is the specific recognition of the viral genome with the maturing virus capsid leading to encapsidation (packaging) of the genome to the protective capsid. The formed and released viral particle is metastable, being primed to deliver the genome upon interaction with a new host cell. Viruses with an RNA genome either condense their nucleic acid concomitantly with the capsid assembly or produce empty capsids (procapsids), which translocate the viral genome into the particle in reaction requiring chemical energy in a form of NTPs. RNA viruses can have one to twelve genome segments. It is obvious that very delegate mechanisms have evolved to assure specific packaging of the entire genome either to a single or several particles.
- Viral RNA-protein Interactions;
- Virus Genome;
- Virus Genome Packaging