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Cancer Chemotherapy, Theoretical Foundations of


  1. Nicholas B. La Thangue

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200300175

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

La Thangue, N. B. 2006. Cancer Chemotherapy, Theoretical Foundations of. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. University of Glasgow, Division of Biochemistry and Molecular Biology, Glasgow, UK

Publication History

  1. Published Online: 15 SEP 2006

This is not the most recent version of the article. View current version (27 JAN 2016)


The massive research efforts that have been applied to understanding the workings of the cancer cell have provided a wealth of detail on key mechanisms that become abnormal during tumorigenesis. Translating and exploiting this large body of cancer research information in the design and implementation of new drugs should yield better medicines for the cancer patient than those that are currently available. It is an implicit assumption in this objective that mechanism-based agents that target discrete abnormalities in tumor cells will provide improved treatments over conventional therapies. In this respect, we are beginning to witness emerging clinical efficacy in a new generation of cancer drugs designed to target key mechanisms in tumor cells.


  • Cancer;
  • Drug Design;
  • Therapy;
  • p53;
  • Cell Cycle;
  • Angiogenesis;
  • Hsp90;
  • Erb B;
  • E2F