Standard Article

Computational Biology

Systems Biology

  1. Thomas Lengauer,
  2. Mario Albrecht,
  3. Francisco S. Domingues

Published Online: 15 MAY 2012

DOI: 10.1002/3527600906.mcb.200400023.pub2

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Lengauer, T., Albrecht, M. and Domingues, F. S. 2012. Computational Biology. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. Max Planck Institute for Informatics, Department of Computational Biology and Applied Algorithmics, Saarbrücken, Germany

Publication History

  1. Published Online: 15 MAY 2012


During recent years, biological research has become increasingly based on large-scale experimentation such that data may be collected on an organismic scale. These data are voluminous, they are often very noisy, and their interpretation – and the configuration of the experiments involved – necessitates complex computer analysis. The respective computer methods are themselves an object of intensive research in a scientific discipline known as “computational biology” or “bioinformatics.” Computational biology has a wide variety of facets that range from experiment configuration and low-level data analysis to computer-generated hypotheses.


  • Sequence alignment;
  • Phylogeny reconstruction;
  • Molecular docking;
  • Protein design;
  • Protein structure prediction;
  • Protein function prediction;
  • Molecular network;
  • Computational immunology;
  • Bioinformatical resistance analysis