Malaria Mosquito Genome
Molecular Biology of Specific Organisms
Published Online: 15 SEP 2006
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA. All rights reserved.
Reviews in Cell Biology and Molecular Medicine
How to Cite
Holt, R. A. and Collins, F. H. 2006. Malaria Mosquito Genome. Reviews in Cell Biology and Molecular Medicine. .
- Published Online: 15 SEP 2006
Mosquito-borne illnesses exact an enormous toll on human health; malaria parasites alone currently infect approximately 500 million people, more than 1 million of whom will die this year. A. gambiae is the principal malaria vector in sub-Saharan Africa, where 90% of the world's deaths due to malaria occur. Historically, the greatest successes in prevention of malaria, yellow fever, and other mosquito-borne disease have come from controlling the mosquito vector. Current work on vector control holds much promise and can be addressed more efficiently by genomic approaches. The reference genome sequence of A. gambiae sensu stricto (a representative member of the cryptic A. gambiae species complex) has yielded novel insecticide targets, has facilitated the identification of genes involved in insecticide resistance, and has led to the identification of genes that underlie the strong preference of this vector for human blood. Germ-line transformation of the mosquito has been achieved and the reference genome sequence will facilitate efforts to develop a tractable genetic control strategy for mosquitoes. The publication of the A. gambiae genome is a landmark in medical entomology, both because this was the first vector genome to be fully sequenced and because of the impact of this mosquito on public health.
- Cytogenetic Form;
- Mate Pair;