Standard Article

Malaria Mosquito Genome

Molecular Biology of Specific Organisms

  1. Robert A. Holt1,
  2. Frank H. Collins2

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200400056

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Holt, R. A. and Collins, F. H. 2006. Malaria Mosquito Genome. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. 1

    Canada's Michael Smith Genome Science Centre, Vancouver, BC, Canada

  2. 2

    University of Notre Dame, Notre Dame, IN, USA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Mosquito-borne illnesses exact an enormous toll on human health; malaria parasites alone currently infect approximately 500 million people, more than 1 million of whom will die this year. A. gambiae is the principal malaria vector in sub-Saharan Africa, where 90% of the world's deaths due to malaria occur. Historically, the greatest successes in prevention of malaria, yellow fever, and other mosquito-borne disease have come from controlling the mosquito vector. Current work on vector control holds much promise and can be addressed more efficiently by genomic approaches. The reference genome sequence of A. gambiae sensu stricto (a representative member of the cryptic A. gambiae species complex) has yielded novel insecticide targets, has facilitated the identification of genes involved in insecticide resistance, and has led to the identification of genes that underlie the strong preference of this vector for human blood. Germ-line transformation of the mosquito has been achieved and the reference genome sequence will facilitate efforts to develop a tractable genetic control strategy for mosquitoes. The publication of the A. gambiae genome is a landmark in medical entomology, both because this was the first vector genome to be fully sequenced and because of the impact of this mosquito on public health.

Keywords:

  • BAC;
  • Contig;
  • Cytogenetic Form;
  • DDT;
  • Mate Pair;
  • Orthologs;
  • Paralogs;
  • PEST;
  • Read;
  • SNP;
  • Scaffold;
  • Vector;
  • WHO;
  • Shotgun;
  • Sporogeny