Standard Article

Proteasomes

Cell Biology

  1. Martin Rechsteiner

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200400063

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Rechsteiner, M. 2006. Proteasomes. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. Department of Biochemistry University of Utah, Salt Lake, UT, USA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

The 20S proteasome was discovered in 1980 and the 26S proteasome six years later. Research over the past two decades has made it abundantly clear that the Ub-proteasome system is of central importance in eukaryotic cell physiology and medicine. At the cellular and biochemical levels, there are a number of unresolved problems. We need a crystal structure of the 19S RC, or better yet, the 26S proteasome, for they would surely provide an insight into the mechanism by which the 26S proteasome degrades its substrates. How the 26S proteasome itself is regulated and the extent to which proteasomal components vary among tissues in higher eukaryotes are other important unresolved problems. As for the medical perspective, we need to know how many diseases will be found to arise because of defects in the ubiquitin–proteasome system. Hopefully, these problems will generate research on the UPS by some readers of this article.

Keywords:

  • AAA ATPases;
  • Aggresome;
  • Base;
  • Chaperone;
  • COP9 Signalosome (Csn);
  • Degron;
  • Ecm29;
  • Epoxomicin;
  • Hybrid Proteasome;
  • Immunoproteasome;
  • Lactacystin;
  • Lid;
  • Metabolic Regulation;
  • PA28s (aka 11S REGs);
  • PA200;
  • Proteasome Activators;
  • 20S Proteasome;
  • 26S Proteasome;
  • 19S Regulatory Complex (aka PA700);
  • Ubiquitin;
  • VCP;
  • Velcade