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Lipoprotein Analysis

Biochemistry

  1. Alan T. Remaley1,
  2. G. Russell Warnick2

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200400085

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Remaley, A. T. and Warnick, G. R. 2006. Lipoprotein Analysis. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. 1

    National Institutes of Health, MD, USA

  2. 2

    Pacific Biometrics Research Foundation Issaquah, WA, USA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Lipoproteins are submicron- to micron-sized particles that are composed of both lipids and proteins. Lipoproteins are the major extracellular carrier of lipids, such as cholesterol, and thus, they play an important role in the pathogenesis of atherosclerosis. The analysis of lipoproteins is performed in most clinical laboratories to identify patients at risk of coronary heart disease (CHD). Lipoprotein analysis is also essential in monitoring the effectiveness of cholesterol-lowering therapy.

The focus of this chapter will be on methods for lipoprotein analysis that are used for routine diagnostic purposes, but in addition, new promising types of lipoprotein analysis that are still in the realm of basic research will also be highlighted. A brief description of lipid biochemistry and lipoprotein metabolism will be followed by a review of commonly used methods for analyzing lipoproteins. Finally, the chapter will conclude with a summary of how the results of lipoprotein analysis are used in the diagnosis and management of patients with dyslipidemias.

Keywords:

  • Apolipoprotein;
  • Atherosclerosis;
  • Cholesterol;
  • Coronary Artery Disease;
  • Lipoprotein