Standard Article

Matrix, Extracellular and Interstitial

Cell Biology

  1. Abebe Akalu,
  2. Peter C. Brooks

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200400091

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Akalu, A. and Brooks, P. C. 2006. Matrix, Extracellular and Interstitial. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. New York University School of Medicine, NY, USA

Publication History

  1. Published Online: 15 SEP 2006


The requirement of bidirectional communication between cells and their local acellular microenvironment for proper development and homeostasis in multicellular organisms has been appreciated for decades. Interestingly, intriguing new studies have suggested that some of this molecular information may be cryptic or hidden within the three-dimensional architecture of proteins and requires structural modification of the ECM for efficient transmission and utilization by cells and tissues. Thus, the dynamic interplay between cells and both intact and structurally altered ECM proteins help establish specificity, coordinate, and refine the complex interconnected biological responses critical for normal physiological processes. In this regard, unique insight will likely be gained into pathological events by a more complete understanding of the integrated network of molecular signals regulated by cellular interactions with the ECM.


  • Basement Membrane (BM);
  • Cryptic ECM Epitope;
  • Extracellular Matrix (ECM);
  • Interstitial Matrix;
  • Matricellular Proteins