Membrane Traffic: Vesicle Budding and Fusion
Published Online: 15 SEP 2006
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA. All rights reserved.
Reviews in Cell Biology and Molecular Medicine
How to Cite
Clague, M. J. and Urbé, S. 2006. Membrane Traffic: Vesicle Budding and Fusion. Reviews in Cell Biology and Molecular Medicine. .
- Published Online: 15 SEP 2006
Tight control of the flux of membrane components through vesicle budding and fusion is essential to cellular organization, giving rise to subcellular compartments with distinct functions. Cargo is generally selected for inclusion into vesicles by specific sorting signals, which are recognized by adaptor proteins, that link to protein components of vesicle coats. The membrane deformation required for vesicle formation is promoted by the coat complex in conjunction with accessory proteins, which may partially insert into the bilayer membrane. Specific targeting of vesicles is initially mediated through “tethering” molecules and then cemented through interactions between SNARE proteins, which also catalyze fusion. The essential mechanisms are conserved throughout the cell and from yeast to man.
- Coated Vesicle;
- Membrane Fusion;
- Rab Protein;
- Secretory Pathway;
- SNARE Protein