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Membrane Traffic: Vesicle Budding and Fusion

Cell Biology

  1. Michael J. Clague,
  2. Sylvie Urbé

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200400097

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Clague, M. J. and Urbé, S. 2006. Membrane Traffic: Vesicle Budding and Fusion. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. University of Liverpool, Liverpool, UK

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Tight control of the flux of membrane components through vesicle budding and fusion is essential to cellular organization, giving rise to subcellular compartments with distinct functions. Cargo is generally selected for inclusion into vesicles by specific sorting signals, which are recognized by adaptor proteins, that link to protein components of vesicle coats. The membrane deformation required for vesicle formation is promoted by the coat complex in conjunction with accessory proteins, which may partially insert into the bilayer membrane. Specific targeting of vesicles is initially mediated through “tethering” molecules and then cemented through interactions between SNARE proteins, which also catalyze fusion. The essential mechanisms are conserved throughout the cell and from yeast to man.

Keywords:

  • Clathrin;
  • Coated Vesicle;
  • Endocytosis;
  • Membrane Fusion;
  • Rab Protein;
  • Secretory Pathway;
  • SNARE Protein