Published Online: 15 SEP 2006
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA. All rights reserved.
Reviews in Cell Biology and Molecular Medicine
How to Cite
Ploss, A. and Pamer, E. G. 2006. Immunologic Memory. Reviews in Cell Biology and Molecular Medicine. .
- Published Online: 15 SEP 2006
Immunologic memory provides long-term protection against infectious pathogens and is the basis for all vaccinations. Long-term protection is mediated by specialized antigen-specific cells of the adaptive immune system, memory T- and B cell, as well as plasma cells. In response to an invading pathogen, naïve T cells specific for foreign antigen are primed by dendritic cells, expand and differentiate into effector cells that contribute to the clearance of the infection. After the initial immune response, most expanded T cells die and a small population of long-lived memory cells remains. Memory cells are qualitatively distinct from their antigen-inexperienced precursors since they proliferate and acquire their effector functions more rapidly upon repeat exposure to antigen.
- Adaptive Immune Response;
- Affinity Maturation;
- Clusters of Differentiation (CD);
- Cytotoxic T cell (CTL);
- Dendritic Cells (DCs);
- Helper CD4+ T Cell (Th Cells);
- Interleukin (IL);
- Lymphatic System;
- Major Histocompatibility Complex (MHC);
- Plasma Cells;
- T-Cell Receptor (TCR);