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Immunosuppressive Factors in Cancer

Molecular Biology of Specific Diseases

  1. Jeremy E. Moss1,
  2. Christine N. Metz2,
  3. Richard Bucala1

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200400129

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Moss, J. E., Metz, C. N. and Bucala, R. 2006. Immunosuppressive Factors in Cancer. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. 1

    Yale University School of Medicine, New Haven, CT, USA

  2. 2

    North Shore-Long Island Jewish Research Institute, Manhasset, NY, USA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Tumor cells avoid attack from the host immune system by expressing a variety of different molecules including: cytokines, prostaglandins, polyamines, enzymes, cell surface receptors, and shed antigens. Cancers that are successful in evading host antitumor defenses tend to persist, enlarge, and ultimately metastasize. Thus, an accurate identification and understanding of the various immunosuppressive factors that tumor cells employ to impair the host immune response is critical for the development of effective treatments for cancer patients. Overcoming these evasive mechanisms may be the last major obstacle to the generation of universally successful cancer therapeutics.

Keywords:

  • Anergy;
  • Indoleamine 2,3-dioxygenase;
  • Polyamines;
  • Tolerance;
  • Tumor Infiltrating Lymphocyte