Immune Defence, Cell Mediated
Published Online: 15 SEP 2006
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA. All rights reserved.
Reviews in Cell Biology and Molecular Medicine
How to Cite
Bachmann, M. F. and Kundig, T. M. 2006. Immune Defence, Cell Mediated. Reviews in Cell Biology and Molecular Medicine. .
- Published Online: 15 SEP 2006
Many cell types make up the arsenal of the immune system and are directly involved in the destruction of invading pathogens. Broadly, two types of cells can be distinguished: firstly, some cells recognize signals that are associated with pathogens, such as tissue damage or patterns found on pathogens but not in the host. These cells belong to the innate immune system and appeared first during evolution. The second type of cells, the lymphocyte, has developed a complex machinery that allows each lymphocyte to express a single and unique receptor with random specificity, the B- and T-cell receptors. Once these receptors recognize a pathogen, the lymphocyte encoding the receptor undergoes clonal expansion and the lymphocyte population differentiates into effector cells, ridding the pathogen. Lymphocytes therefore make up the specific or adaptive immune system. This article discusses how the various cell types protect from infection with pathogens and elucidates some of the complex interactions between the two systems.
- B cells;
- T cells;
- T helper cells (Th cells);
- Th1 cells;
- Th2 cells;
- Cytotoxic T cells (CTLs);
- Dendritic cells (DCs)