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Virus-free Gene Transfer Systems in Somatic Gene Therapy

Pharmacology

  1. Oliver Kayser1,
  2. Albrecht F. Kiderlen2

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200500003

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Kayser, O. and Kiderlen, A. F. 2006. Virus-free Gene Transfer Systems in Somatic Gene Therapy. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. 1

    Pharmaceutical Biology, Rijksuniversiteit Groningen, Groningen, The Netherlands

  2. 2

    Robert Koch-Institut, Berlin, Germany

Publication History

  1. Published Online: 15 SEP 2006

Abstract

In somatic gene therapy, nucleic acid is transferred into and subsequently expressed in somatic cells (i.e. not in stem cells) in order to alter or substitute gene functions as a means of prophylactic or therapeutic treatment of patients. The nucleic acid itself is the pharmaceutical drug. For transfer of genes, viral (retro, adeno, and adenovirus-associated viruses), physical (electroporation and bioballistics), and chemical systems are utilized. Chemical and physical systems are united as nonviral systems.

Keywords:

  • Liposomes;
  • Somatic;
  • Transfection;
  • Vectors