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Regulation of Stem Cell Populations

Cell Biology

  1. Daniela Drummond-Barbosa

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200500015

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Drummond-Barbosa, D. 2006. Regulation of Stem Cell Populations. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. Vanderbilt University School of Medicine, Nashville, TN

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Stem cells are essential for the health of multicellular organisms, as they give rise to all cells of the body during embryonic development, and in adults, maintain the integrity and function of many tissues. Stem cells are functionally defined as cells that have the extended ability to self-renew and to give rise to various cell types present in a given tissue. The behavior of stem cells is remarkably context dependent, underscoring both the existence of complex regulatory mechanisms involved in their maintenance and function, as well as the inherent difficulties of studying their biology in a nonadulterating manner. Despite these difficulties, intense research has revealed that their regulation is achieved via the orchestration of cell-intrinsic factors, locally secreted factors, and extrinsic signals impinging on the tissue. As knowledge of the mechanisms of stem cell regulation expands through the combined study of powerful model systems, we will continue to gain valuable insights into how to manipulate stem cells for the welfare of human kind.

Keywords:

  • Basement Membrane;
  • Germline;
  • Knockout Mouse;
  • Model Organisms;
  • Niche;
  • Self-renewal;
  • Transgenic Animal;
  • Transit Amplifying Cells