Published Online: 15 SEP 2006
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA
Encyclopedia of Molecular Cell Biology and Molecular Medicine
How to Cite
Mouland, A. J., Gatignol, A. and Heveker, N. 2006. Virus-Cell Interactions. Encyclopedia of Molecular Cell Biology and Molecular Medicine. .
- Published Online: 15 SEP 2006
Viruses are obligatory parasites of their host cells. During the viral replication cycle, many host-cell components are co-opted or hijacked to favor viral replication and virus production. The interactions between the virus and the host induce multiple cellular responses that modify normal cell function and can lead either to clearing of the virus or to enhanced virus replication and pathogenesis. Most, if not all steps of the viral replication cycle are characterized by critical virus–host interactions. These begin with the earliest steps of the replication cycle (e.g. viral entry into the target cell) to later steps including mRNA synthesis, genome replication, and protein and viral genome trafficking within the nucleus and cytoplasm to sites of viral assembly. The understanding of the molecular details of these virus-cell interactions will ultimately help in the design of new and specific therapies against viral infection. The purpose of this review is to highlight various virus–cell interactions. Because of the extensive nature of this topic, we will be presenting general themes and specific examples of virus–cell interactions where appropriate rather than a comprehensive catalog of every virus–cell interaction that has been uncovered.
- Attachment Factor;
- Innate Immunity;
- Intracellular Trafficking;
- Viral Restriction