Standard Article

Targeted Therapy: Genomic Approaches

  1. Anna C. Maroney,
  2. Sergey E. Ilyin

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200500039

Encyclopedia of Molecular Cell Biology and Molecular Medicine

Encyclopedia of Molecular Cell Biology and Molecular Medicine

How to Cite

Maroney, A. C. and Ilyin, S. E. 2006. Targeted Therapy: Genomic Approaches. Encyclopedia of Molecular Cell Biology and Molecular Medicine. .

Author Information

  1. Johnson & Johnson Pharmaceutical Research & Development, Spring House, PA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

The concept of Targeted Therapy was developed over the past 10 years and it relies on inhibition of specific signaling pathways, as opposed to nonspecific chemotherapy. Consequently, if targeted pathways are differentially activated between normal and malignant cells, significantly fewer side effects would be expected in clinical settings. Translocations and other genomic changes that occur in malignancies lead to activation of specific signaling pathways and/or enzymatic cascades, which can be specifically and selectively addressed with therapeutic agents.

Keywords:

  • Biomarker;
  • Functional Informatics;
  • Targeted Therapy