Targeted Therapy: Genomic Approaches
Published Online: 15 SEP 2006
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA
Encyclopedia of Molecular Cell Biology and Molecular Medicine
How to Cite
Maroney, A. C. and Ilyin, S. E. 2006. Targeted Therapy: Genomic Approaches. Encyclopedia of Molecular Cell Biology and Molecular Medicine. .
- Published Online: 15 SEP 2006
The concept of Targeted Therapy was developed over the past 10 years and it relies on inhibition of specific signaling pathways, as opposed to nonspecific chemotherapy. Consequently, if targeted pathways are differentially activated between normal and malignant cells, significantly fewer side effects would be expected in clinical settings. Translocations and other genomic changes that occur in malignancies lead to activation of specific signaling pathways and/or enzymatic cascades, which can be specifically and selectively addressed with therapeutic agents.
- Functional Informatics;
- Targeted Therapy