Standard Article

Vaccine Approaches for Protection Against HIV

Biotechnology

  1. Stephen M. Smith1,
  2. Mahender Singh1,
  3. Kuan-Teh Jeang2

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200500047

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Smith, S. M., Singh, M. and Jeang, K.-T. 2006. Vaccine Approaches for Protection Against HIV. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. 1

    Saint Michael's Medical Center & New Jersey Medical School, Newark, NJ, USA

  2. 2

    Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD, USA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/ AIDS) has reached pandemic proportions globally. Currently, there are approximately 40 million individuals infected with HIV-1. The most likely solution for this disease is a preventive vaccine that can be distributed worldwide. Despite intense efforts, the development of a vaccine against HIV has not been realized. Here, we review the challenges that have impeded progress and the approaches that are currently under consideration. Vaccination results from human trials and animal models are also discussed.

Keywords:

  • AIDS;
  • CTL;
  • DNA;
  • HIV;
  • SIV;
  • Vaccine